To describe the management of endodontic-periodontal lesion attributable to palatogingival groove extending from crown to root surface, contributing to severe periodontal breakdown in relation to maxillary central incisor.Palatogingival groove may act as a nidus of plaque accumulation and contribute to the pathogenesis of endodontic-periodontal les
A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice.
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally.MiRNAs are implicated in various biological processes associated with obesity, including adipocyte differentiation and lipid metabolism.We used a neuronal-specific inhibition of miRNA maturation in adult mice to study the consequences of miRN
Induced protein expression in Leptospira spp. and its application to CRISPR/Cas9 mutant generation
Abstract Expanding the genetic toolkit for Leptospira spp.is a crucial step toward advancing our understanding of the biology and virulence of these atypical bacteria.Pathogenic Leptospira are responsible for over 1 million human leptospirosis cases annually and significantly impact domestic animals.Bovine leptospirosis causes substantial financial
Type I error control for cluster randomized trials under varying small sample structures
Abstract Background Linear mixed models (LMM) are a common approach to analyzing data from cluster randomized trials (CRTs).Inference on parameters can be performed via Wald tests or likelihood ratio tests (LRT), but both approaches may give incorrect Type I error rates Audio Video Adaptor in common finite sample settings.The impact of different co